I managed to get it working previously and did and animation with the the regular setting. Made a sprite recently and for some reason it slows down when I try to manipulate it in skins.
I tried making a small one with just one piece and it seemed like it worked. I assuming my comp specs should be good enough to handle.
This is my comp build.
https://pcpartpicker.com/user/Nerilla/saved/9tbjZL
The sprite is about 14 pieces. Size around 1200x800. Last thing I did was give it take the same size.