To use bounding boxes precalculated in Spriter for correct clipping and effects, in Spriter, simply click on the box icon on the animation widget. Use settings roughly like what you see below:
framerate: In order to calculate a bounding box that takes tweening into account, Spriter will go through the animation at a set framerate. 60 is recommended.
padding: Extra pixels added to each side of the bounding box to ensure that frames in between the above calculated don't go slightly outside. 0 is probably fine for most cases, but 1 or 2 pixels isn't going to affect your performance and makes doubly sure.
The best workflow would probably be to run the calculation once on all animations the first time you use it, and each time you add an animation. After that, only bother recalculating the bounding box if new animation changes massively affect the bounding box, or if you notice any clipping at runtime. And of course, run it once before shipping or demoing your game.